| http://purl.uniprot.org/citations/28947618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28947618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28947618 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of intron-containing genes in eukaryotes requires generation of protein-coding messenger RNAs (mRNAs) via RNA splicing, whereby the spliceosome removes non-coding introns from pre-mRNAs and joins exons. Spliceosomes must ensure accurate removal of highly diverse introns. We show that Sde2 is a ubiquitin-fold-containing splicing regulator that supports splicing of selected pre-mRNAs in an intron-specific manner in Schizosaccharomyces pombe Both fission yeast and human Sde2 are translated as inactive precursor proteins harbouring the ubiquitin-fold domain linked through an invariant GGKGG motif to a C-terminal domain (referred to as Sde2-C). Precursor processing after the first di-glycine motif by the ubiquitin-specific proteases Ubp5 and Ubp15 generates a short-lived activated Sde2-C fragment with an N-terminal lysine residue, which subsequently gets incorporated into spliceosomes. Absence of Sde2 or defects in Sde2 activation both result in inefficient excision of selected introns from a subset of pre-mRNAs. Sde2 facilitates spliceosomal association of Cactin/Cay1, with a functional link between Sde2 and Cactin further supported by genetic interactions and pre-mRNA splicing assays. These findings suggest that ubiquitin-like processing of Sde2 into a short-lived activated form may function as a checkpoint to ensure proper splicing of certain pre-mRNAs in fission yeast."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201796751"xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201796751"xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Datta S."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Datta S."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Mishra S.K."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Mishra S.K."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Pleiss J.A."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Pleiss J.A."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Kolathur K.K."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Kolathur K.K."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Pandit P.A."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Pandit P.A."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Thakran P."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/author | "Thakran P."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/pages | "89-101"xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/pages | "89-101"xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/title | "Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing."xsd:string |
| http://purl.uniprot.org/citations/28947618 | http://purl.uniprot.org/core/title | "Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing."xsd:string |