| http://purl.uniprot.org/citations/28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28948716 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and aimsEmerging evidence shows that fibroblast growth factor 22 (FGF22) plays a critical role in the etiology of depression. However, the molecular mechanisms of FGF22 are not fully comprehended. Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments.MethodsSerum from depressive patients was collected, and the levels of FGF22 and IL-1β were analyzed by ELISA. The chronic unpredictable mild stress (CUMS) model was established, and primary hippocampal neuronal cells were cultured to examine changes in FGF22 and IL-1β levels in rat hippocampus.ResultsThe results revealed a negative correlation between serum FGF22 levels and serum IL-1β levels. The expression of IL-1β in the CUMS rat hippocampus decreased, and the apoptosis of hippocampal cells improved after the injection of lentiviral vector-mediated FGF22 (LV-FGF22). Further tests in primary hippocampal neuronal cells also showed a reduction in IL-1β and the cell apoptosis rate after treatment with FGF22.ConclusionIn conclusion, the results revealed that FGF22 plays a role in alleviating depression, which may be mediated by reduced expression of IL-1β."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.org/dc/terms/identifier | "doi:10.1111/cns.12760"xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/author | "Li Y.F."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/author | "Yao S."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/author | "Chen S.Y."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/author | "Xu Y.H."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/author | "Zhu X.L."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/name | "CNS Neurosci Ther"xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/pages | "907-916"xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/title | "Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1beta."xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/28948716 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28948716 |
| http://purl.uniprot.org/citations/28948716 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28948716 |
| http://purl.uniprot.org/uniprot/#_A0A7U3L4H9-mappedCitation-28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28948716 |
| http://purl.uniprot.org/uniprot/#_A0A7U3JVZ9-mappedCitation-28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28948716 |
| http://purl.uniprot.org/uniprot/#_A6K8X7-mappedCitation-28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28948716 |
| http://purl.uniprot.org/uniprot/#_K7ELB9-mappedCitation-28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28948716 |
| http://purl.uniprot.org/uniprot/#_O60371-mappedCitation-28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28948716 |
| http://purl.uniprot.org/uniprot/#_Q9HCT0-mappedCitation-28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28948716 |
| http://purl.uniprot.org/uniprot/#_Q8VI79-mappedCitation-28948716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28948716 |
| http://purl.uniprot.org/uniprot/A6K8X7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28948716 |