DESCRIBE <http://purl.uniprot.org/citations/28950256>

Subject	Predicate	Object
http://purl.uniprot.org/citations/28950256	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28950256	http://www.w3.org/2000/01/rdf-schema#comment	" Background/aims Increasing evidence has shown that miR-125a plays important role in human cancer progression. However, little is known about the function of miR-125a in osteosarcoma. Methods The expression of miR-125a in osteosarcoma tissues and cell lines were examined by qRT-PCR. The biological role of miR-125a in osteosarcoma cell proliferation was examined in vitro. The targets of miR-125a were identified by a dual-luciferase reporter assay. Results The results showed that the expression of miR-125a expression is significantly lower in osteosarcoma tissues and cell lines. Survival curves showed that the survival of patients in high miR-125a expression was significantly longer than that of patients with low miR-125a expression, and multivariate analysis suggested that miR-125a is an independent prognostic factor for osteosarcoma patients. In addition, it was found in this study that miR-125a can inhibit the growth of osteosarcoma cells. The dual-luciferase reporter assay demonstrated that E2F2 is a novel target gene for miR-125a. In addition, in a recovery experiment, it was shown that miR-125a inhibits the biological function of osteosarcoma cells by inhibiting the expression of E2F2. Conclusion Our results suggest that miR-125a acts as a tumor suppressor via regulation of E2F2 expression in osteosarcoma progression, and miR-125a may represent a novel therapeutic target for the treatment of osteosarcoma."xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.org/dc/terms/identifier	"doi:10.1159/000481560"xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/author	"Luo J."xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/author	"Shen Q."xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/author	"Xu Y."xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/author	"Liang W."xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/author	"Tao T."xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/date	"2017"xsd:gYear
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/name	"Cell Physiol Biochem"xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/pages	"768-774"xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/title	"MicroRNA-125a Regulates Cell Proliferation Via Directly Targeting E2F2 in Osteosarcoma."xsd:string
http://purl.uniprot.org/citations/28950256	http://purl.uniprot.org/core/volume	"43"xsd:string
http://purl.uniprot.org/citations/28950256	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/28950256
http://purl.uniprot.org/citations/28950256	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/28950256
http://purl.uniprot.org/uniprot/#_Q14209-mappedCitation-28950256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28950256
http://purl.uniprot.org/uniprot/#_Q5U0J0-mappedCitation-28950256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28950256
http://purl.uniprot.org/uniprot/#_Q96ID7-mappedCitation-28950256	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28950256
http://purl.uniprot.org/uniprot/Q14209	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28950256
http://purl.uniprot.org/uniprot/Q96ID7	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28950256
http://purl.uniprot.org/uniprot/Q5U0J0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28950256