| http://purl.uniprot.org/citations/28954632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28954632 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe objective of this study was to compare the efficacy of biomarkers in assessing the risk of breast cancer recurrence in patients with node-negative or micrometastatic grade II breast cancer. Specifically, we compared risk assessments based on the St. Gallen clinicopathological criteria, Ki67 expression and urokinase plasminogen activator (uPA)/plasminogen activator inhibitor-1 (PAI-1) expression.MethodsThis retrospective study included 347 patients with breast cancer followed at Limoges University Hospital. The optimal cut-off for high Ki67 expression (Ki67hi) was established as 20%. The threshold for uPA and PAI-1 positivity was 3 ng/mg and 14 ng/mg, respectively.ResultsKi67 expression was lower in uPA/PAI-1-negative than in uPA/PAI-1-positive tumours (227 tumours; P = 0.04). The addition of Ki67 status to the St. Gallen criteria resulted in a 28% increase in the rate of identification of high-risk tumours with a potential indication for chemotherapy (P < 0.001). When considering uPA/PAI-1 levels together with the St Gallen criteria (including Ki67 expression), the number of cases identified as having a high recurrence risk with a potential indication for adjuvant chemotherapy increased by 20% (P < 0.001). Adjuvant chemotherapy was 9% less likely to be recommended by a multidisciplinary board when using the current criteria compared with using a combination of the St. Gallen criteria and Ki67 and uPA/PAI-1 status (P = 0.03).ConclusionsTaken together, our data show discordance among markers in identifying the risk of recurrence, even though each marker may prove to be independently valid."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12885-017-3648-z"xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Saidi N."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Venat-Bouvet L."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Fermeaux V."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Leobon S."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Tubiana-Mathieu N."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Deluche E."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Aubard Y."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Jammet I."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/author | "Mollard J."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/name | "BMC Cancer"xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/pages | "662"xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/title | "Assessment of Ki67 and uPA/PAI-1 expression in intermediate-risk early stage breast cancers."xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/28954632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28954632 |
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