| http://purl.uniprot.org/citations/28955046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28955046 | http://www.w3.org/2000/01/rdf-schema#comment | "Sporadic aortic aneurysm and dissections (AADs) are common vascular diseases that carry a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with thrombospondin motifs-4) is a secreted proteinase involved in inflammation and matrix degradation. We previously showed ADAMTS-4 levels were increased in human sporadic descending thoracic AAD (TAAD) samples. Here, we provide evidence that ADAMTS-4 contributes to aortic destruction and sporadic AAD development. In a mouse model of sporadic AAD induced by a high-fat diet and angiotensin II infusion, ADAMTS-4 deficiency (Adamts-4-/-) significantly reduced challenge-induced aortic diameter enlargement, aneurysm formation, dissection and aortic rupture. Aortas in Adamts-4-/-mice showed reduced elastic fibre destruction, versican degradation, macrophage infiltration, and apoptosis. Interestingly, ADAMTS-4 was directly involved in smooth muscle cell (SMC) apoptosis. Under stress, ADAMTS-4 translocated to the nucleus in SMCs, especially in apoptotic SMCs. ADAMTS-4 directly cleaved and degraded poly ADP ribose polymerase-1 (a key molecule in DNA repair and cell survival), leading to SMC apoptosis. Finally, we showed significant ADAMTS-4 expression in aortic tissues from patients with sporadic ascending TAAD, particularly in SMCs. Our findings indicate that ADAMTS-4 induces SMC apoptosis, degrades versican, promotes inflammatory cell infiltration, and thus contributes to sporadic AAD development."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-12248-z"xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Shen Y.H."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Ren P."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Coselli J.S."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "LeMaire S.A."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Milewicz D.M."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Zou S."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Hughes M."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Krishnamoorthy S."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/author | "Curci J.A."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/pages | "12351"xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/title | "Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice."xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28955046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28955046 |
| http://purl.uniprot.org/citations/28955046 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28955046 |
| http://purl.uniprot.org/uniprot/#_E0CZC0-mappedCitation-28955046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28955046 |
| http://purl.uniprot.org/uniprot/#_A0A384ME91-mappedCitation-28955046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28955046 |
| http://purl.uniprot.org/uniprot/#_A8K6A8-mappedCitation-28955046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28955046 |