| http://purl.uniprot.org/citations/28958656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28958656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28958656 | http://www.w3.org/2000/01/rdf-schema#comment | "Dental caries, which affects billions of people, is a chronic infectious disease that involves Streptococcus mutans, which is nevertheless a poor predictor of individual caries development. We therefore investigated if adhesin types of S.mutans with sucrose-independent adhesion to host DMBT1 (i.e. SpaP A, B or C) and collagen (i.e. Cnm, Cbm) match and predict individual differences in caries development. The adhesin types were measured in whole saliva by qPCR in 452 12-year-old Swedish children and related to caries at baseline and prospectively at a 5-year follow-up. Strains isolated from the children were explored for genetic and phenotypic properties. The presence of SpaP B and Cnm subtypes coincided with increased 5-year caries increment, and their binding to DMBT1 and saliva correlated with individual caries scores. The SpaP B subtypes are enriched in amino acid substitutions that coincided with caries and binding and specify biotypes of S. mutans with increased acid tolerance. The findings reveal adhesin subtypes of S. mutans that match and predict individual differences in caries development and provide a rationale for individualized oral care."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2017.09.027"xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2017.09.027"xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Persson K."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Persson K."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Esberg A."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Esberg A."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Sheng N."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Sheng N."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Boren T."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Boren T."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Stromberg N."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Stromberg N."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Claesson R."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Claesson R."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Marell L."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/author | "Marell L."xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/pages | "205-215"xsd:string |
| http://purl.uniprot.org/citations/28958656 | http://purl.uniprot.org/core/pages | "205-215"xsd:string |