| http://purl.uniprot.org/citations/28960134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28960134 | http://www.w3.org/2000/01/rdf-schema#comment | "The recruitment of endoplasmic reticulum (ER) components to dendritic cell (DC) phagosomes and endosomes is a crucial event to achieve efficient cross-presentation of exogenous antigens. We have previously identified the small GTPase Rab22a as a key regulator of MHC-I trafficking and antigen cross-presentation by DCs. In this study we show that low expression of Rab22a does not prevent the normal delivery of ER-derived proteins to DC phagosomes. In contrast, the presence of these proteins was diminished in endosomes labelled with a fluid phase marker. These observations were confirmed by a functional assay that assesses the translocation of a soluble protein to the cytosol. Interestingly, we also demonstrate that early endosomal maturation is altered in Rab22a deficient DCs. Our results indicate that Rab22a plays a major role in endosomal function and highlight the importance of studying the endocytic and phagocytic pathways separately in DCs."xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.org/dc/terms/identifier | "doi:10.1080/21541248.2017.1384088"xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/author | "Croce C."xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/author | "Mayorga L.S."xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/author | "Cebrian I."xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/name | "Small GTPases"xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/pages | "211-219"xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/title | "Differential requirement of Rab22a for the recruitment of ER-derived proteins to phagosomes and endosomes in dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/28960134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28960134 |
| http://purl.uniprot.org/citations/28960134 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28960134 |
| http://purl.uniprot.org/uniprot/#_Q96IY7-mappedCitation-28960134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28960134 |
| http://purl.uniprot.org/uniprot/#_Q9UL26-mappedCitation-28960134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28960134 |
| http://purl.uniprot.org/uniprot/Q9UL26 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28960134 |
| http://purl.uniprot.org/uniprot/Q96IY7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28960134 |