| http://purl.uniprot.org/citations/28963466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28963466 | http://www.w3.org/2000/01/rdf-schema#comment | "Pro-inflammatory cytokines are known to induce endothelial cell autophagy, but the role of autophagy in regulating the expression of pro-inflammatory molecules has not been characterized. We hypothesized that autophagy facilitates expression of endothelial adhesion molecules. TNFα and IL-1β induced autophagy markers in human umbilical vein endothelial cells and inhibition of autophagy by 3-methyladenine (3-MA) blocked adhesion of Jurkat lymphocytes. Interestingly, 3-MA suppressed VCAM-1 but not ICAM-1 expression at 24 hours but not 6 hours. 3-MA suppressed VCAM-1 transcription and decreased nuclear NF-κB p65 level at 6 hours but not at 2 hours. Cytokines induced a biphasic degradation of IκBα and 3-MA selectively blocked the late-phase IκBα degradation. Our results suggest that cytokine-induced autophagy contributes to late-phase IκBα degradation, facilitates NF-κB nuclear translocation and VCAM-1 transcription for long-term VCAM-1 expression. With a cytokines array assay, we found that 3-MA also inhibited IP-10 expression. These findings provide new information about the role of endothelial autophagy in persistent expression of VCAM-1 and IP-10 which enhance lymphocyte recruitment and adhesion to endothelium."xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-12641-8"xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/author | "Wu K.K."xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/author | "Hsueh Y.C."xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/author | "Chu L.Y."xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/author | "Cheng H.L."xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/pages | "12472"xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/title | "Cytokine-induced autophagy promotes long-term VCAM-1 but not ICAM-1 expression by degrading late-phase IkappaBalpha."xsd:string |
| http://purl.uniprot.org/citations/28963466 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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