| http://purl.uniprot.org/citations/28966044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28966044 | http://www.w3.org/2000/01/rdf-schema#comment | "Age-dependent ectopic fat accumulation (EFA) in animals contributes to the progression of tissue aging and diseases such as obesity, diabetes, and cancer. However, the primary causes of age-dependent EFA remain largely elusive. Here, we characterize the occurrence of age-dependent EFA in Drosophila and identify HDAC6, a cytosolic histone deacetylase, as a suppressor of EFA. Loss of HDAC6 leads to significant age-dependent EFA, lipid composition imbalance, and reduced animal longevity on a high-fat diet. The EFA and longevity phenotypes are ameliorated by a reduction of the lipid-droplet-resident protein PLIN2. We show that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2. These findings indicate that proteostasis collapse serves as an intrinsic cue to cause age-dependent EFA. Our study suggests that manipulation of proteostasis could be an alternative approach to the treatment of age-related metabolic diseases such as obesity and diabetes."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2017.09.001"xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Lam S.M."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Shui G."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Deng W.M."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Jiao R."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/author | "Lindstrom-Battle A."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/pages | "99-111.e5"xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/title | "HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/28966044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28966044 |
| http://purl.uniprot.org/citations/28966044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28966044 |
| http://purl.uniprot.org/uniprot/M9PJN5#attribution-BE002E8920A251C3D72354357F809B87 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28966044 |