| http://purl.uniprot.org/citations/28970581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28970581 | http://www.w3.org/2000/01/rdf-schema#comment | "Regeneration of injured skeletal muscles relies on a tightly controlled chain of cellular and molecular events. We show that appropriate levels of S100B protein are required for timely muscle regeneration after acute injury. S100B released from damaged myofibers and infiltrating macrophages expands the myoblast population, attracts macrophages and promotes their polarization into M2 (pro-regenerative) phenotype, and modulates collagen deposition, by interacting with RAGE (receptor for advanced glycation end-products) or FGFR1 (fibroblast growth factor receptor 1) depending on the muscle repair phase and local conditions. However, persistence of high S100B levels compromises the regeneration process prolonging myoblast proliferation and macrophage infiltration, delaying M1/M2 macrophage transition, and promoting deposition of fibrotic tissue via RAGE engagement. Interestingly, S100B is released in high abundance from degenerating muscles of mdx mice, an animal model of Duchenne muscular dystrophy (DMD), and blocking S100B ameliorates histopathology. Thus, levels of S100B differentially affect skeletal muscle repair upon acute injury and in the context of muscular dystrophy, and S100B might be regarded as a potential molecular target in DMD."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-12880-9"xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Donato R."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Giambanco I."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Bereshchenko O."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Riccardi C."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Sorci G."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Riuzzi F."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Beccafico S."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Sagheddu R."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/author | "Chiappalupi S."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/pages | "12537"xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/title | "Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy."xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28970581 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28970581 |
| http://purl.uniprot.org/citations/28970581 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28970581 |
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| http://purl.uniprot.org/uniprot/#_A0A023ZTV5-mappedCitation-28970581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28970581 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1NN66-mappedCitation-28970581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28970581 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS2-mappedCitation-28970581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28970581 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS4-mappedCitation-28970581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28970581 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS6-mappedCitation-28970581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28970581 |