| http://purl.uniprot.org/citations/28972140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28972140 | http://www.w3.org/2000/01/rdf-schema#comment | "αβ T cell receptors (TCRs) interact with peptides bound to the polymorphic major histocompatibility complex class Ia (MHC-Ia) and class II (MHC-II) molecules as well as the essentially monomorphic MHC class Ib (MHC-Ib) molecules. Although there is a large amount of information on how TCRs engage with MHC-Ia and MHC-II, our understanding of TCR/MHC-Ib interactions is very limited. Infection with cytomegalovirus (CMV) can elicit a CD8+ T cell response restricted by the human MHC-Ib molecule human leukocyte antigen (HLA)-E and specific for an epitope from UL40 (VMAPRTLIL), which is characterized by biased TRBV14 gene usage. Here we describe an HLA-E-restricted CD8+ T cell able to recognize an allotypic variant of the UL40 peptide with a modification at position 8 (P8) of the peptide (VMAPRTLVL) that uses the TRBV9 gene segment. We report the structures of a TRBV9+ TCR in complex with the HLA-E molecule presenting the two peptides. Our data revealed that the TRBV9+ TCR adopts a different docking mode and molecular footprint atop HLA-E when compared with the TRBV14+ TCR-HLA-E ternary complex. Additionally, despite their differing V gene segment usage and different docking mechanisms, mutational analyses showed that the TCRs shared a conserved energetic footprint on the HLA-E molecule, focused around the peptide-binding groove. Hence, we provide new insights into how monomorphic MHC molecules interact with T cells."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m117.807719"xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Farenc C."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Lee E.J."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Beddoe T."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Brooks A.G."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Clements C.S."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Falco M."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Moretta L."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Pietra G."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Sullivan L.C."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Mingari M.C."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Walpole N.G."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/author | "Sum M.J.W."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/pages | "21149-21158"xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/title | "A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct alphabeta T cell receptors."xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://purl.uniprot.org/core/volume | "292"xsd:string |
| http://purl.uniprot.org/citations/28972140 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28972140 |
| http://purl.uniprot.org/citations/28972140 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28972140 |
| http://purl.uniprot.org/uniprot/#_A0A0F7WBW2-mappedCitation-28972140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28972140 |