| http://purl.uniprot.org/citations/28987344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28987344 | http://www.w3.org/2000/01/rdf-schema#comment | "Non-Homologous End Joining (NHEJ) is a highly conserved pathway that repairs Double-Strand Breaks (DSBs) within DNA. Here we show that the deletion of yeast uncharacterized ORF HUR1, Hydroxyurea Resistance1 affects the efficiency of NHEJ. Our findings are supported by Protein-Protein Interaction (PPI), genetic interaction and drug sensitivity analyses. To assess the activity of HUR1 in DSB repair, we deleted its non-overlapping region with PMR1, referred to as HUR1-A. We observed that similar to deletion of TPK1 and NEJ1, and unlike YKU70 (important for NHEJ of DNA with overhang and not blunt end), deletion of HUR1-A reduced the efficiency of NHEJ in both overhang and blunt end plasmid repair assays. Similarly, a chromosomal repair assay showed a reduction for repair efficiency when HUR1-A was deleted. In agreement with a functional connection for Hur1p with Tpk1p and NEJ1p, double mutant strains Δhur1-A/Δtpk1, and Δhur1-A/Δnej1 showed the same reduction in the efficiency of plasmid repair, compared to both single deletion strains. Also, using a Homologous Recombination (HR) specific plasmid-based DSB repair assay we observed that deletion of HUR1-A influenced the efficiency of HR repair, suggesting that HUR1 might also play additional roles in other DNA repair pathways."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2017.10.003"xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Sanders M."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Daniel M."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Ramotar D."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Babu M."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Golshani A."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Samanfar B."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Jessulat M."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Omidi K."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Dehne F."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Burnside D."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Hooshyar M."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Schoenrock A."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Bhojoo U."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Hajikarimlou M."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Kazmirchuk T."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/author | "Moteshareie H."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/pages | "128-136"xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/title | "Uncharacterized ORF HUR1 influences the efficiency of non-homologous end-joining repair in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://purl.uniprot.org/core/volume | "639"xsd:string |
| http://purl.uniprot.org/citations/28987344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28987344 |