| http://purl.uniprot.org/citations/28991229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28991229 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia is a driver of cell movement in processes such as development and tumor progression. The cellular response to hypoxia involves a transcriptional program mediated by hypoxia-inducible factors, but translational control has emerged as a significant contributor. In this study, we demonstrate that a cell-cell adhesion molecule, cadherin-22, is upregulated in hypoxia via mTORC1-independent translational control by the initiation factor eIF4E2. We identify new functions of cadherin-22 as a hypoxia-specific cell-surface molecule involved in cancer cell migration, invasion and adhesion. Silencing eIF4E2 or cadherin-22 significantly impaired MDA-MB-231 breast carcinoma and U87MG glioblastoma cell migration and invasion only in hypoxia, while reintroduction of the respective exogenous gene restored the normal phenotype. Cadherin-22 was evenly distributed throughout spheroids and required for their formation and support of a hypoxic core. Conversely, E-cadherin translation was repressed by hypoxia and only expressed in the oxygenated cells of U87MG spheroids. Furthermore, immunofluorescence on paraffin-embedded human tissue from 40 glioma and 40 invasive ductal breast carcinoma patient specimens revealed that cadherin-22 expression colocalized with areas of hypoxia and significantly correlated with tumor grade and progression-free survival or stage and tumor size, respectively. This study broadens our understanding of tumor progression and metastasis by highlighting cadherin-22 as a potential new target of cancer therapy to disable hypoxic cancer cell motility and adhesion."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2017.372"xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/author | "Coomber B.L."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/author | "Kelly N.J."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/author | "Uniacke J."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/author | "Romeo C.M."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/author | "Specker E.J."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/author | "Varga J.F.A."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/pages | "651-662"xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/title | "Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion."xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/28991229 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28991229 |
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