| http://purl.uniprot.org/citations/28993399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28993399 | http://www.w3.org/2000/01/rdf-schema#comment | "For organs to achieve their proper size, the processes of stem cell renewal and differentiation must be tightly regulated. We previously showed that in the developing kidney, Wnt9b regulates distinct β-catenin-dependent transcriptional programs in the renewing and differentiating populations of the nephron progenitor cells. How β-catenin stimulated these two distinct programs was unclear. Here, we show that β-catenin cooperates with the transcription factor Myc to activate the progenitor renewal program. Although in multiple contexts Myc is a target of β-catenin, our characterization of a cell type-specific enhancer for the Wnt9b/β-catenin target gene Fam19a5 shows that Myc and β-catenin cooperate to activate gene expression controlled by this element. This appears to be a more general phenomenon as we find that Myc is required for the expression of every Wnt9b/β-catenin progenitor renewal target assessed as well as for proper nephron endowment in vivo This study suggests that, within the developing kidney, tissue-specific β-catenin activity is regulated by cooperation with cell type-specific transcription factors. This finding not only provides insight into the regulation of β-catenin target genes in the developing kidney, but will also advance our understanding of progenitor cell renewal in other cell types/organ systems in which Myc and β-catenin are co-expressed."xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.153700"xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/author | "Pan X."xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/author | "Carroll T.J."xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/author | "Karner C.M."xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/pages | "4173-4182"xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/title | "Myc cooperates with beta-catenin to drive gene expression in nephron progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/28993399 | http://purl.uniprot.org/core/volume | "144"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A2ABR0-mappedCitation-28993399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28993399 |