| http://purl.uniprot.org/citations/29017771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29017771 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL) 13 plays a critical role in inflammatory diseases, including systemic lupus erythematosus (SLE). This study aims to explore the potential association of IL-13 polymorphisms with the risk of SLE. We genotyped IL-13 rs20541, rs848 and rs1295686 using Snapshot SNP genotyping assays. Plasma IL-13 level was determined by enzyme-linked immunosorbent assay (ELISA). We found that rs20541 was associated with increased risk of SLE (CT vs. CC: adjusted OR=1.43, 95%CI, 1.04-1.99, P=.030; TT vs. CC: adjusted OR=1.73, 95%CI, 1.10-2.73, P=.018; CT/TT vs. CC: adjusted OR=1.50, 95%CI, 1.10-2.04, P=.010; T vs. C adjusted OR=1.34, 95%CI, 1.08-1.93, P=.031). CT and TT genotypes in rs20541 were associated with increased risk of renal disorder in SLE (CT vs. CC: adjusted OR=1.97, 95%CI, 1.18-3.28, P=.009; TT vs. CC: adjusted OR=2.42, 95%CI, 1.22-4.77, P=.011). Moreover, The concentration of IL-13 was significantly elevated in rs20541 CT/TT genotypes compared with CC genotype (P<.001). These results suggest that rs20541 CT/TT genotypes may be a risk factor for SLE, probably by increasing the level of IL-13."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2017.09.034"xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Wang J.L."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Lu Y.L."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Lan Y."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Huang H.T."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Qin H.M."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Wang C.F."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/author | "Wei Y.S."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/pages | "92-97"xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/title | "Association of interleukin 13 gene polymorphisms and plasma IL 13 level with risk of systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/29017771 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29017771 |
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