| http://purl.uniprot.org/citations/29025991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29025991 | http://www.w3.org/2000/01/rdf-schema#comment | "Central to CD8+ T cell-mediated immunity is the recognition of peptide-major histocompatibility complex class I (p-MHC I) proteins displayed by antigen-presenting cells. Chaperone-mediated loading of high-affinity peptides onto MHC I is a key step in the MHC I antigen presentation pathway. However, the structure of MHC I with a chaperone that facilitates peptide loading has not been determined. We report the crystal structure of MHC I in complex with the peptide editor TAPBPR (TAP-binding protein-related), a tapasin homolog. TAPBPR remodels the peptide-binding groove of MHC I, resulting in the release of low-affinity peptide. Changes include groove relaxation, modifications of key binding pockets, and domain adjustments. This structure captures a peptide-receptive state of MHC I and provides insights into the mechanism of peptide editing by TAPBPR and, by analogy, tapasin."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aao5154"xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/author | "Natarajan K."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/author | "Margulies D.H."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/author | "Boyd L.F."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/author | "Mage M.G."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/author | "Morozov G.I."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/pages | "1064-1068"xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/title | "Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation."xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://purl.uniprot.org/core/volume | "358"xsd:string |
| http://purl.uniprot.org/citations/29025991 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29025991 |
| http://purl.uniprot.org/citations/29025991 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29025991 |
| http://purl.uniprot.org/uniprot/#_P61769-mappedCitation-29025991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29025991 |
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| http://purl.uniprot.org/uniprot/#_P01900-mappedCitation-29025991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29025991 |
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| http://purl.uniprot.org/uniprot/#_Q9BX59-mappedCitation-29025991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29025991 |
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