| http://purl.uniprot.org/citations/29027900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29027900 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with slowed RNAPII elongation. Here, we identify a site of ubiquitination (K1246) in the catalytic subunit of RNAPII close to the DNA entry path. Ubiquitination was increased in the absence of the Bre5-Ubp3 ubiquitin protease complex. Bre5 binds RNA in vivo, with a preference for exon 2 regions of intron-containing pre-mRNAs and poly(A) proximal sites. Ubiquitinated RNAPII showed similar enrichment. The absence of Bre5 led to impaired splicing and defects in RNAPII elongation in vivo on a splicing reporter construct. Strains expressing RNAPII with a K1246R mutation showed reduced co-transcriptional splicing. We propose that ubiquinitation of RNAPII is induced by RNA processing events and linked to transcriptional pausing, which is released by Bre5-Ubp3 associated with the nascent transcript."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.27082"xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Rappsilber J."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Allshire R."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Beggs J.D."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Milligan L."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Tollervey D."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Kudla G."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Alves F.L."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Spanos C."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Alexander R."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Auchynnikava T."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Reid J.E."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Sayou C."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/author | "Tuck A."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/pages | "e27082"xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/title | "RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit."xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/29027900 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29027900 |
| http://purl.uniprot.org/citations/29027900 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29027900 |
| http://purl.uniprot.org/uniprot/#_A0A8H4F991-mappedCitation-29027900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29027900 |
| http://purl.uniprot.org/uniprot/#_A0A8H8UM15-mappedCitation-29027900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29027900 |