| http://purl.uniprot.org/citations/29028794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29028794 | http://www.w3.org/2000/01/rdf-schema#comment | "LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This work reveals that the human Condensin II complex restricts L1 retrotransposition in both non-transformed and transformed cell lines through inhibition of L1 transcription and translation. Condensin II subunits, CAP-D3 and CAP-H2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex including the glutamyl-prolyl-tRNA synthetase (EPRS), the ribosomal protein L13a, Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and NS1 associated protein 1 (NSAP1). GAIT has been shown to inhibit translation of mRNAs encoding inflammatory proteins in myeloid cells by preventing the binding of the translation initiation complex, in response to Interferon gamma (IFN-γ). Excitingly, our data show that Condensin II promotes complexation of GAIT subunits. Furthermore, RNA-Immunoprecipitation experiments in epithelial cells demonstrate that Condensin II and GAIT subunits associate with L1 RNA in a co-dependent manner, independent of IFN-γ. These findings suggest that cooperation between the Condensin II and GAIT complexes may facilitate a novel mechanism of L1 repression, thus contributing to the maintenance of genome stability in somatic cells."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1007051"xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Willard B."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Fox P.L."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Longworth M.S."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Halawani D."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Moran J.V."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Larson P.A."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Vasu K."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Ward J.R."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/author | "Deutschman E."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/pages | "e1007051"xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/title | "Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/29028794 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29028794 |
| http://purl.uniprot.org/citations/29028794 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29028794 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YYG7-mappedCitation-29028794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29028794 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-29028794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29028794 |
| http://purl.uniprot.org/uniprot/#_A8YQE4-mappedCitation-29028794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29028794 |
| http://purl.uniprot.org/uniprot/#_A1Z2M2-mappedCitation-29028794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29028794 |
| http://purl.uniprot.org/uniprot/#_G3V1A9-mappedCitation-29028794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29028794 |