| http://purl.uniprot.org/citations/29033321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29033321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29033321 | http://www.w3.org/2000/01/rdf-schema#comment | "N6-methyladenosine (m6A) is an essential internal RNA modification that is critical for gene expression control in most organisms. Proteins with a YTH domain recognize m6A marks and are mediators of molecular functions like RNA splicing, mRNA decay, and translation control. Here we demonstrate that YTH domain-containing 2 (YTHDC2) is an m6A reader that is essential for male and female fertility in mice. High-throughput mapping of the m6A transcriptome and expression analysis in the Yhtdc2 mutant testes reveal an upregulation of m6A-enriched transcripts. Our biochemical studies indicate that YTHDC2 is an RNA-induced ATPase with a 3'→5' RNA helicase activity. Furthermore, YTHDC2 recruits the 5'→3' exoribonuclease XRN1 via Ankyrin repeats that are inserted in between the RecA modules of the RNA helicase domain. Our studies reveal a role for YTHDC2 in modulating the levels of m6A-modified germline transcripts to maintain a gene expression program that is conducive for progression through meiosis."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.09.021"xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.09.021"xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Wojtas M.N."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Wojtas M.N."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Sachidanandam R."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Sachidanandam R."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Pandey R.R."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Pandey R.R."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Pillai R.S."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Pillai R.S."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Homolka D."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Homolka D."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Mendel M."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/author | "Mendel M."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/pages | "374-387"xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/pages | "374-387"xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/title | "Regulation of m6A transcripts by the 3'-5' RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline."xsd:string |
| http://purl.uniprot.org/citations/29033321 | http://purl.uniprot.org/core/title | "Regulation of m6A transcripts by the 3'-5' RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline."xsd:string |