| http://purl.uniprot.org/citations/29036225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29036225 | http://www.w3.org/2000/01/rdf-schema#comment | "C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a). C1-INH treatment reduced Th2 response and enhanced HDM-specific IgG1. Influx of eosinophils in BALF or lung, pulmonary damage, mucus production, procoagulant response or plasma leakage in BALF was similar in both groups. In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0186652"xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "van 't Veer C."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "van der Poll T."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Engel R."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Wouters D."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Zeerleder S."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "van Mierlo G."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Roem D."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Anas A.A."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Stroo I."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "de Boer J.D."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/author | "Roelofs J.J.T.H."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/pages | "e0186652"xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/title | "Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice."xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/29036225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29036225 |
| http://purl.uniprot.org/citations/29036225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29036225 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z333-mappedCitation-29036225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29036225 |
| http://purl.uniprot.org/uniprot/#_E9PK97-mappedCitation-29036225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29036225 |
| http://purl.uniprot.org/uniprot/#_A0A384MDV8-mappedCitation-29036225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29036225 |