| http://purl.uniprot.org/citations/29037857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29037857 | http://www.w3.org/2000/01/rdf-schema#comment | "The intracellular proinflammatory mediator IL-32 is associated with tumor progression; however, the mechanisms remain unknown. We studied IL-32 mRNA expression as well as expression of other proinflammatory cytokines and mediators, including IL-1α, IL-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, the proangiogenic and antiapoptotic enzyme cyclooxygenase-2, the IL-8 receptor C-X-C chemokine receptor (CXCR) 1, and the intracellular kinase focal adhesion kinase-1. The interaction of IL-32 expression with expression of IL-6, TNF-α, IL-8, and cyclooxygenase-2 was also investigated. Biopsy specimens of 11 HIV-related, 7 non-HIV-related Kaposi sarcoma (KS), and 7 normal skin tissues (NSTs) of Dutch origin were analyzed. RNA was isolated from the paraffin material, and gene expression levels of IL-32 α, β, and γ isoforms, IL1a, IL1b, IL6, IL8, TNFA, PTGS2, CXCR1, and PTK2 were determined using real-time quantitative PCR. Significantly higher expression of IL-32β and IL-32γ isoforms was observed in HIV-related KS biopsy specimens compared with non-HIV-related KS and NST. The splicing ratio of the IL-32 isoforms showed IL-32γ as the highest expressed isoform, followed by IL-32β, in HIV-related KS cases compared with non-HIV-related KS and NST. Our data suggest a possible survival mechanism by the splicing of IL-32γ to IL-32β and also IL-6, IL-8, and CXCR1 signaling pathways to reverse the proapoptotic effect of the IL-32γ isoform, leading to tumor cell survival and thus favoring tumor progression."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2017.08.033"xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Plantinga T.S."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Joosten L.A.B."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Kibiki G."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Sonda T."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Heinhuis B."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Blokx W.A.M."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Semango G."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Masenga E.J."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Mavura D."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "Nyindo M."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/author | "van der Ven A.J.A.M."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/pages | "196-203"xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/title | "Exploring the Role of IL-32 in HIV-Related Kaposi Sarcoma."xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/29037857 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29037857 |
| http://purl.uniprot.org/citations/29037857 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29037857 |
| http://purl.uniprot.org/uniprot/#_C6GKH1-mappedCitation-29037857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29037857 |
| http://purl.uniprot.org/uniprot/#_C6GKH2-mappedCitation-29037857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29037857 |
| http://purl.uniprot.org/uniprot/#_G3LU47-mappedCitation-29037857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29037857 |
| http://purl.uniprot.org/uniprot/#_P24001-mappedCitation-29037857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29037857 |