| http://purl.uniprot.org/citations/29042409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29042409 | http://www.w3.org/2000/01/rdf-schema#comment | "Sgs1, the orthologue of human Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair. We show that SGS1 loss increases R-loop accumulation and sensitizes cells to transcription-replication collisions. Yeast lacking SGS1 accumulate R-loops and γ-H2A at sites of Sgs1 binding, replication pausing regions, and long genes. The mutation signature of sgs1Δ reveals copy number changes flanked by repetitive regions with high R-loop-forming potential. Analysis of BLM in Bloom's syndrome fibroblasts or by depletion of BLM from human cancer cells confirms a role for Sgs1/BLM in suppressing R-loop-associated genome instability across species. In support of a potential direct effect, BLM is found physically proximal to DNA:RNA hybrids in human cells, and can efficiently unwind R-loops in vitro. Together, our data describe a conserved role for Sgs1/BLM in R-loop suppression and support an increasingly broad view of DNA repair and replication fork stabilizing proteins as modulators of R-loop-mediated genome instability."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201703168"xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Jones S.J.M."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Kobor M.S."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Masson J.Y."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Chaturvedi R."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Coulombe Y."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Stirling P.C."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Aristizabal M.J."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Segovia R."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Tam A.S."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Chang E.Y."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Novoa C.A."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/author | "Keong C."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/pages | "3991-4005"xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/title | "RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability."xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://purl.uniprot.org/core/volume | "216"xsd:string |
| http://purl.uniprot.org/citations/29042409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29042409 |
| http://purl.uniprot.org/citations/29042409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29042409 |
| http://purl.uniprot.org/uniprot/#_P54132-mappedCitation-29042409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29042409 |
| http://purl.uniprot.org/uniprot/#_A0A8H4F849-mappedCitation-29042409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29042409 |