| http://purl.uniprot.org/citations/29044125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29044125 | http://www.w3.org/2000/01/rdf-schema#comment | "The epidermal permeability barrier (EPB) prevents organisms from dehydration and infection. The transcriptional regulation of EPB development is poorly understood. We demonstrate here that transcription factor COUP-TF-interacting protein 1 (CTIP1/BCL11A; hereafter CTIP1) is highly expressed in the developing murine epidermis. Germline deletion of Ctip1 (Ctip1 -/-) results in EPB defects accompanied by compromised epidermal differentiation, drastic reduction in profilaggrin processing, reduced lamellar bodies in granular layers and significantly altered lipid composition. Transcriptional profiling of Ctip1 -/- embryonic skin identified altered expression of genes encoding lipid-metabolism enzymes, skin barrier-associated transcription factors and junctional proteins. CTIP1 was observed to interact with genomic elements within the regulatory region of the gene encoding the differentiation-associated gene, Fos-related antigen2 (Fosl2) and lipid-metabolism-related gene, Fatty acid elongase 4 (Elvol4), and the expression of both was altered in Ctip1 -/- mice. CTIP1 appears to play a role in EPB establishment of via direct or indirect regulation of a subset of genes encoding proteins involved in epidermal differentiation and lipid metabolism. These results identify potential, CTIP1-regulated avenues for treatment of skin disorders involving EBP defects."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-13347-7"xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Messaddeq N."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Leid M."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Bauer E.M."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Hendrix D.A."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Indra A.K."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Ganguli-Indra G."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/author | "Teegarden A."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/pages | "13427"xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/title | "Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development."xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/29044125 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29044125 |
| http://purl.uniprot.org/citations/29044125 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29044125 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW46-mappedCitation-29044125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29044125 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWE2-mappedCitation-29044125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29044125 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX57-mappedCitation-29044125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29044125 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXG4-mappedCitation-29044125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29044125 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXH0-mappedCitation-29044125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29044125 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXI5-mappedCitation-29044125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29044125 |