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http://purl.uniprot.org/citations/29050484http://www.w3.org/2000/01/rdf-schema#comment"

Background

This study aimed to evaluate whether VNTR variants in the Endothelial Nitric Oxide Synthase (eNOS) and the XRCC4 gene play any role in nicotine dependence (ND) and/or Schizophrenia+ND (Sch+ND) ethiopathogenesis.

Methods

Present study included 100 individuals with ND, 60 patients with Sch+ND, and 70 healthy controls. These variants were analyzed using PCR.

Results

The cases with ND had higher eNOS VNTR-BB genotype than the healthy control subjects (p = 0.001). eNOS-AA genotype was lower in cases with Sch+ND and ND groups compared to the controls (p = 0.001, p = 0.001, respectively). eNOS-B allele was found significantly more frequently in Sch+ND group compared to the controls (p = 0.001). eNOS-A allele was significantly lower in ND group than the controls (p = 0.001). XRCC4-ID genotype was more common in the ND group than the control group (p = 0.001) as heterozygosity disadvantage. XRCC4-DD genotype was more common in the Sch+ND group compared to the controls (p = 0.035). The frequency of XRCC4-I allele was lower in the Sch+ND group compared to the controls (p = 0.012).

Conclusions

Our results showed that eNOS and XRCC4 VNTR variants might play a potential role in Sch+ND and/or ND pathophysiology (Tab. 2, Ref. 48)."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.org/dc/terms/identifier"doi:10.4149/bll_2017_090"xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Uysal S."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Pehlivan S."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Pehlivan M."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Aydin N."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Nursal A.F."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Aydin P.C."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Kurnaz S."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Sever U."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Uysal M.A."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Yavuz F.K."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/author"Yavuzlar H."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/name"Bratisl Lek Listy"xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/pages"467-471"xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/title"eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia."xsd:string
http://purl.uniprot.org/citations/29050484http://purl.uniprot.org/core/volume"118"xsd:string
http://purl.uniprot.org/citations/29050484http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29050484
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