| http://purl.uniprot.org/citations/29056325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29056325 | http://www.w3.org/2000/01/rdf-schema#comment | "The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3. PI(3,4,5)P3 can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P2. The PTEN tumor suppressor is thought to function primarily as a PI(3,4,5)P3 3-phosphatase, limiting activation of this pathway. Here we show that PTEN also functions as a PI(3,4)P2 3-phosphatase, both in vitro and in vivo. PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated cells. PTEN deletion increased PI(3,4)P2 levels in a mouse model of prostate cancer, and it inversely correlated with PI(3,4)P2 levels across several EGF-stimulated prostate and breast cancer lines. These results point to a role for PI(3,4)P2 in the phenotype caused by loss-of-function mutations or deletions in PTEN."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.09.024"xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Le Novere N."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Sasaki T."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Nakanishi H."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Clark J."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Sasaki J."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Hawkins P.T."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Kielkowska A."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Niewczas I."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Stephens L.R."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Imbert M."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Eguchi S."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Anderson K.E."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Koizumi A."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Beinke S."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Habuchi T."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Pir P."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Gray A."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Barneda D."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Spensberger D."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Malek M."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Juvin V."xsd:string |
| http://purl.uniprot.org/citations/29056325 | http://purl.uniprot.org/core/author | "Cosulich S."xsd:string |