| http://purl.uniprot.org/citations/29069597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29069597 | http://www.w3.org/2000/01/rdf-schema#comment | "Transient reduced food intake (hypophagia) following high stress could have beneficial effects on longevity, but paradoxically, hypophagia can persist and become anorexia-like behavior. The neural underpinnings of stress-induced hypophagia and the mechanisms by which the brain prevents the transition from transient to persistent hypophagia remain undetermined. In this study, we report the involvement of a network governing goal-directed behavior (decision). This network consists of the ascending serotonergic inputs from the dorsal raphe nucleus (DR) to the medial prefrontal cortex (mPFC). Specifically, adult restoration of serotonin 4 receptor (5-HT4R) expression in the mPFC rescues hypophagia and specific molecular changes related to depression resistance in the DR (5-HT release elevation, 5-HT1A receptor, and 5-HT transporter reductions) of stressed 5-HT4R knockout mice. The adult mPFC-5-HT4R knockdown mimics the null phenotypes. When mPFC-5-HT4Rs are overexpressed and DR-5-HT1ARs are blocked in the DR, hypophagia following stress persists, suggesting an antidepressant action of early anorexia."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.10.003"xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Maroteaux L."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Doly S."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Jean A."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Laurent L."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Neve R."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Compan V."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Linden D."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Delaunay S."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Dusticier N."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/author | "Nieoullon A."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/pages | "901-909"xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/title | "Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress."xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/29069597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29069597 |
| http://purl.uniprot.org/citations/29069597 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29069597 |
| http://purl.uniprot.org/uniprot/#_A0A494BA82-mappedCitation-29069597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29069597 |
| http://purl.uniprot.org/uniprot/#_G8H732-mappedCitation-29069597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29069597 |
| http://purl.uniprot.org/uniprot/#_G8H733-mappedCitation-29069597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29069597 |
| http://purl.uniprot.org/uniprot/#_G8H734-mappedCitation-29069597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29069597 |
| http://purl.uniprot.org/uniprot/#_G8H735-mappedCitation-29069597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29069597 |