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http://purl.uniprot.org/citations/29070503http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29070503http://www.w3.org/2000/01/rdf-schema#comment"Adiponectin regulates endothelial nitric oxide synthase in endothelial cells, and body fat loss by aerobic exercise training promotes adiponectin secretion. Recently, C1q/tumor necrosis factor-related proteins (CTRPs) have been identified as novel adipokines and are paralogs of adiponectin, but the association between exercise training-induced reduction of arterial stiffness and circulating CTRPs levels remains unclear. This study aimed to clarify whether the reduction of arterial stiffness in middle-aged and older adults is associated with the change in serum levels of CTRPs induced by exercise training. A total of 52 middle-aged and older participants were randomly divided into two groups: a training group ( n = 26) and a sedentary control group ( n = 26). Participants in the training group completed 8 wk of aerobic exercise training (60-70% peak oxygen uptake for 45 min, 3 days/wk). The reduction of percent whole body fat, abdominal visceral fat area, and carotid-femoral pulse-wave velocity (cfPWV) was significantly greater in the training group than in the control group ( P < 0.05). Moreover, the increase in serum adiponectin, CTRP3, and CTRP5 from baseline to 8 wk was significantly higher in the training group compared with the control group ( P < 0.05). Additionally, the training-induced change in cfPWV was negatively correlated with the training-induced change in serum adiponectin, CTRP3, and CTRP5 levels ( r = -0.51, r = -0.48, r = -0.42, respectively, P < 0.05), and increased plasma nitrite/nitrate level by exercise training was correlated only with adiponectin levels ( r = 0.41, P < 0.05). These results suggest that the exercise training-induced increase in serum CTRPs levels may be associated with the reduction of arterial stiffness in middle-aged and older adults."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.org/dc/terms/identifier"doi:10.1152/ajpregu.00212.2017"xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Kurihara T."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Uchida M."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Hamaoka T."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Hasegawa N."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Sanada K."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Iemitsu M."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Fujie S."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/author"Horii N."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/name"Am J Physiol Regul Integr Comp Physiol"xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/pages"R94-R101"xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/title"Aerobic exercise training-induced changes in serum C1q/TNF-related protein levels are associated with reduced arterial stiffness in middle-aged and older adults."xsd:string
http://purl.uniprot.org/citations/29070503http://purl.uniprot.org/core/volume"314"xsd:string
http://purl.uniprot.org/citations/29070503http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29070503
http://purl.uniprot.org/citations/29070503http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29070503
http://purl.uniprot.org/uniprot/#_A0A024R3F8-mappedCitation-29070503http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29070503
http://purl.uniprot.org/uniprot/#_B3KXI7-mappedCitation-29070503http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29070503
http://purl.uniprot.org/uniprot/#_Q9BXJ0-mappedCitation-29070503http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29070503
http://purl.uniprot.org/uniprot/#_Q9BXJ4-mappedCitation-29070503http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29070503
http://purl.uniprot.org/uniprot/A0A024R3F8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29070503
http://purl.uniprot.org/uniprot/Q9BXJ0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29070503
http://purl.uniprot.org/uniprot/Q9BXJ4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29070503