| http://purl.uniprot.org/citations/29073078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29073078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29073078 | http://www.w3.org/2000/01/rdf-schema#comment | "WT p53 is critical for tumor suppression, whereas mutant p53 promotes tumor progression. Nerve injury-induced protein 1 (Ninj1) is a target of p53 and forms a feedback loop with p53 by repressing p53 mRNA translation. Here, we show that loss of Ninj1 increased mutant p53 expression and, subsequently, enhanced cell growth and migration in cells carrying a mutant p53. In contrast, loss of Ninj1 inhibited cell growth and migration in cells carrying a WT p53. To explore the biological significance of Ninj1, we generated a cohort of Ninj1-deficient mice and found that Ninj1+/- mice were prone to systemic inflammation and insulitis, but not to spontaneous tumors. We also found that loss of Ninj1 altered the tumor susceptibility in both mutant p53 and p53-null background. Specifically, in a mutant p53(R270H) background, Ninj1 deficiency shortened the lifespan, altered the tumor spectrum, and increased tumor burden, likely via enhanced expression of mutant p53. In a p53-null background, Ninj1 deficiency significantly increased the incidence of T-lymphoblastic lymphoma. Taken together, our data suggest that depending on p53 genetic status, Ninj1 has two opposing functions in tumorigenesis and that the Ninj1-p53 loop may be targeted to manage inflammatory diseases and cancer."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1711814114"xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1711814114"xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Yan W."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Yan W."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Yang H.J."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Yang H.J."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Cho S.J."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Cho S.J."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Huang E.C."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Huang E.C."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Lucchesi C."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Lucchesi C."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Scoumanne A."xsd:string |
| http://purl.uniprot.org/citations/29073078 | http://purl.uniprot.org/core/author | "Scoumanne A."xsd:string |