| http://purl.uniprot.org/citations/29079669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29079669 | http://www.w3.org/2000/01/rdf-schema#comment | "RAB-10/Rab10 is a master regulator of endocytic recycling in epithelial cells. To better understand the regulation of RAB-10 activity, we sought to identify RAB-10(GDP)-interacting proteins. One novel RAB-10(GDP)-binding partner that we identified, LET-413, is the Caenorhabditis elegans homologue of Scrib/Erbin. Here, we focus on the mechanistic role of LET-413 in the regulation of RAB-10 within the C. elegans intestine. We show that LET-413 is a RAB-5 effector and colocalizes with RAB-10 on endosomes, and the overlap of LET-413 with RAB-10 is RAB-5 dependent. Notably, LET-413 enhances the interaction of DENN-4 with RAB-10(GDP) and promotes DENN-4 guanine nucleotide exchange factor activity toward RAB-10. Loss of LET-413 leads to cytosolic dispersion of the RAB-10 effectors TBC-2 and CNT-1. Finally, we demonstrate that the loss of RAB-10 or LET-413 results in abnormal overextensions of lateral membrane. Hence, our studies indicate that LET-413 is required for DENN-4-mediated RAB-10 activation, and the LET-413-assisted RAB-5 to RAB-10 cascade contributes to the integrity of C. elegans intestinal epithelia."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201705136"xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Cheng Z."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "He J."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Shi A."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/author | "Hang W."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/pages | "299-314"xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/title | "LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling."xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/29079669 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29079669 |
| http://purl.uniprot.org/citations/29079669 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29079669 |
| http://purl.uniprot.org/uniprot/#_A0A5K1I804-mappedCitation-29079669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29079669 |
| http://purl.uniprot.org/uniprot/#_A0A5K1I8A6-mappedCitation-29079669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29079669 |
| http://purl.uniprot.org/uniprot/#_A0A5K1IAV7-mappedCitation-29079669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29079669 |
| http://purl.uniprot.org/uniprot/#_A0A5K1IC26-mappedCitation-29079669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29079669 |