| http://purl.uniprot.org/citations/29079724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29079724 | http://www.w3.org/2000/01/rdf-schema#comment | "It is generally accepted that voltage-gated Ca2+ channels, CaV, regulate Ca2+ homeostasis in excitable cells following plasma membrane depolarization. Here, we show that the Ca2+ protein α1D of CaV1.3 channel is overexpressed in colorectal cancer biopsies compared to normal tissues. Gene silencing experiments targeting α1D reduced the migration and the basal cytosolic Ca2+ concentration of HCT116 colon cancer cell line and modified the cytosolic Ca2+ oscillations induced by the sodium/calcium exchanger NCX1/3 working in its reverse mode. Interestingly, NCX1/3 regulated membrane potential of HCT116 cells only when α1D was silenced, and blocking NCX1/3 increased cytosolic Ca2+ concentration and cell migration. However, membrane depolarization did not induce an increase in intracellular Ca2+. Patch-clamp experiments clearly showed that the inward Ca2+ current was absent. Finally, flow cytometry and immunofluorescence studies showed that α1D protein was localized at the plasma membrane, in cytosol and cell nuclei. Altogether, we uncover a novel signaling pathway showing that α1D is involved in the regulation of Ca2+ homeostasis and cell migration by a mechanism independent of its plasma membrane canonical function but that involved plasma membrane Na+/Ca2+ exchanger."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-14230-1"xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Lajoie L."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Constantin B."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Felix R."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Gueguinou M."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Bois P."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Potier-Cartereau M."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Vandier C."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Chatelier A."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Magaud C."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Chantome A."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Lecomte T."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Mignen O."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Chamorey E."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Fromont G."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Uguen A."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/author | "Fourbon Y."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/pages | "14199"xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/title | "Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity."xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/29079724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29079724 |