| http://purl.uniprot.org/citations/29084947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29084947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29084947 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy-mediated degradation of synaptic components maintains synaptic homeostasis but also constitutes a mechanism of neurodegeneration. It is unclear how autophagy of synaptic vesicles and components of presynaptic active zones is regulated. Here, we show that Pleckstrin homology containing family member 5 (Plekhg5) modulates autophagy of synaptic vesicles in axon terminals of motoneurons via its function as a guanine exchange factor for Rab26, a small GTPase that specifically directs synaptic vesicles to preautophagosomal structures. Plekhg5 gene inactivation in mice results in a late-onset motoneuron disease, characterized by degeneration of axon terminals. Plekhg5-depleted cultured motoneurons show defective axon growth and impaired autophagy of synaptic vesicles, which can be rescued by constitutively active Rab26. These findings define a mechanism for regulating autophagy in neurons that specifically targets synaptic vesicles. Disruption of this mechanism may contribute to the pathophysiology of several forms of motoneuron disease."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-00689-z"xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-00689-z"xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Jahn R."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Jahn R."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Fuechtbauer A."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Fuechtbauer A."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Fuechtbauer E.M."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Fuechtbauer E.M."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Heimann P."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Heimann P."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Damme M."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Damme M."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Jablonka S."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Jablonka S."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Sendtner M."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Sendtner M."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Petri S."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Petri S."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Blum R."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Blum R."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Maystadt I."xsd:string |
| http://purl.uniprot.org/citations/29084947 | http://purl.uniprot.org/core/author | "Maystadt I."xsd:string |