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http://purl.uniprot.org/citations/29085226http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29085226http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury.

Methods

We investigated thioacetamide (TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma (HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAA-induced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9 (SOX9) and Yes-associated protein (YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.

Results

Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.

Conclusion

STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.org/dc/terms/identifier"doi:10.3748/wjg.v23.i37.6833"xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Nakamura T."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Koga H."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Tanaka T."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Yoshida T."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Abe M."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Masuda A."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Yoshimura A."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Wada F."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Sata M."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Iwamoto H."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Akiba J."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Sakaue T."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Torimura T."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/author"Ikezono Y."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/pages"6833-6844"xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/title"STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury."xsd:string
http://purl.uniprot.org/citations/29085226http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/29085226http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29085226
http://purl.uniprot.org/citations/29085226http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29085226
http://purl.uniprot.org/uniprot/#_B7ZC18-mappedCitation-29085226http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29085226
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