| http://purl.uniprot.org/citations/29091768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29091768 | http://www.w3.org/2000/01/rdf-schema#comment | "Central nervous system (CNS) chemical protection depends upon discrete control of small-molecule access by the blood-brain barrier (BBB). Curiously, some drugs cause CNS side-effects despite negligible transit past the BBB. To investigate this phenomenon, we asked whether the highly BBB-enriched drug efflux transporter MDR1 has dual functions in controlling drug and endogenous molecule CNS homeostasis. If this is true, then brain-impermeable drugs could induce behavioral changes by affecting brain levels of endogenous molecules. Using computational, genetic, and pharmacologic approaches across diverse organisms, we demonstrate that BBB-localized efflux transporters are critical for regulating brain levels of endogenous steroids and steroid-regulated behaviors (sleep in Drosophila and anxiety in mice). Furthermore, we show that MDR1-interacting drugs are associated with anxiety-related behaviors in humans. We propose a general mechanism for common behavioral side effects of prescription drugs: pharmacologically challenging BBB efflux transporters disrupts brain levels of endogenous substrates and implicates the BBB in behavioral regulation."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.10.026"xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Jacobson M.P."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Kitamoto T."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Ishimoto H."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Bainton R.J."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Daneman R."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "DeSalvo M."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Keiser M.J."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Dolghih E."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Munji R.N."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Hindle S.J."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Orng S."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Soung A."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/author | "Gaskins G."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/pages | "1304-1316"xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/title | "Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior."xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/29091768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29091768 |
| http://purl.uniprot.org/citations/29091768 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29091768 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGL4-mappedCitation-29091768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29091768 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0B6-mappedCitation-29091768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29091768 |