| http://purl.uniprot.org/citations/29094110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29094110 | http://www.w3.org/2000/01/rdf-schema#comment | "To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disrupted sleep. The sleep deficits could be reversed and sleep could be enhanced when flies were administered the GABA-A agonist 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol (THIP). Expressing APP:BACE disrupted both Short-term memory (STM) and Long-term memory (LTM) as assessed using Aversive Phototaxic Suppression (APS) and courtship conditioning. Flies expressing APP:BACE also showed reduced levels of the synaptic protein discs large (DLG). Enhancing sleep in memory-impaired APP:BACE flies fully restored both STM and LTM and restored DLG levels. Sleep also restored STM to flies expressing human tau. Using live-brain imaging of individual clock neurons expressing both tau and the cAMP sensor Epac1-camps, we found that tau disrupted cAMP signaling. Importantly, enhancing sleep in flies expressing human tau restored proper cAMP signaling. Thus, we demonstrate that sleep can be used as a therapeutic to reverse deficits that accrue during the expression of toxic peptides associated with Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.nbscr.2016.09.001"xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "Klose M."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "Cao L."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "Shaw P.J."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "Winsky-Sommerer R."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "Dissel S."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "van Swinderen B."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "English D."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/author | "Donlea J."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/name | "Neurobiol Sleep Circadian Rhythms"xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/pages | "15-26"xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/title | "Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/29094110 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29094110 |
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| http://purl.uniprot.org/uniprot/#_E8NH13-mappedCitation-29094110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29094110 |
| http://purl.uniprot.org/uniprot/#_Q4PLW2-mappedCitation-29094110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29094110 |
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