| http://purl.uniprot.org/citations/29097735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29097735 | http://www.w3.org/2000/01/rdf-schema#comment | "AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 subunit exhibit a phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that γ2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f) and ryanodine receptor-derived diastolic local subsarcolemmal Ca2+ release. In contrast, loss of γ2 AMPK induces a reciprocal phenotype of increased heart rate, and prevents the adaptive intrinsic bradycardia of endurance training. Our results reveal that in mammals, for which heart rate is a key determinant of cardiac energy demand, AMPK functions in an organ-specific manner to maintain cardiac energy homeostasis and determines cardiac physiological adaptation to exercise by modulating intrinsic sinoatrial cell behavior."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01342-5"xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "David R."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Nguyen C."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Ramirez C."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Okamoto Y."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Ferguson D.J.P."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Kelly M."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Bright N.J."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Carling D."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Woods A."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Ashrafian H."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Watkins H."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Pinter K."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Douglas G."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "DiFrancesco D."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Sahgal N."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Gomes J."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Schneider J.E."xsd:string |
| http://purl.uniprot.org/citations/29097735 | http://purl.uniprot.org/core/author | "Lakatta E.G."xsd:string |