| http://purl.uniprot.org/citations/29100052 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29100052 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation elongation factors, EF-P in bacteria, or archaeal/eukaryotic a/eIF5A. To date, no structures exist of EF-P or eIF5A in complex with translating ribosomes stalled at polyproline stretches, and thus structural insight into how EF-P/eIF5A rescue these arrested ribosomes has been lacking. Here we present cryo-EM structures of ribosomes stalled on proline stretches, without and with modified EF-P. The structures suggest that the favored conformation of the polyproline-containing nascent chain is incompatible with the peptide exit tunnel of the ribosome and leads to destabilization of the peptidyl-tRNA. Binding of EF-P stabilizes the P-site tRNA, particularly via interactions between its modification and the CCA end, thereby enforcing an alternative conformation of the polyproline-containing nascent chain, which allows a favorable substrate geometry for peptide bond formation."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.10.014"xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Rodnina M.V."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Arenz S."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Huter P."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Wilson D.N."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Starosta A.L."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Tenson T."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Peil L."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Novacek J."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Peske F."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Wohlgemuth I."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Heuer A."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Grubmuller H."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Graf M."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Bock L.V."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Vaiana A.C."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/author | "Frister J.O."xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/pages | "515-527.e6"xsd:string |
| http://purl.uniprot.org/citations/29100052 | http://purl.uniprot.org/core/title | "Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P."xsd:string |