| http://purl.uniprot.org/citations/29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29101097 | http://www.w3.org/2000/01/rdf-schema#comment | "The constitutive androstane receptor (CAR) is a nuclear receptor that acts as a transcription factor for a variety of genes, including genes encoding xenobiotic, steroid, and drug-metabolizing enzymes and transporters. Transactivation of a target gene by a transcription factor is generally mediated through the concerted and stepwise recruitment of various proteins termed coregulators, including coactivators and corepressors. In this study, TRIM24 (also known as transcriptional intermediary factor 1 alpha) was found to interact with the CAR. TRIM24 enhanced the CAR-dependent transactivation in reporter assays using the direct repeat-4 motif, a binding site of the CAR. This enhancement was synergistically augmented in the presence of steroid receptor coactivator (SRC) 1 or SRC2, both of which are coactivators of the CAR. In addition, TRIM24 was recruited to the CAR-binding element of the CYP2B6 promoter together with the CAR. We also noted that knockdown of TRIM24 suppressed CAR-induced CYP2B6 mRNA expression in HepTR/CAR and HepaRG cells and suppressed CAR-induced CYP3A4 mRNA expression in HepaRG cells but not HepTR/CAR cells. From these results, we suggest that TRIM24 is a novel coactivator of the CAR that is involved in cell- and/or promoter- selective transactivation."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.org/dc/terms/identifier | "doi:10.1124/dmd.117.077693"xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Mizuno M."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Tsuchiya Y."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Nemoto K."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Kanno Y."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Inouye Y."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Yamashita N."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/author | "Kure Y."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/name | "Drug Metab Dispos"xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/pages | "46-52"xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/title | "Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor."xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/29101097 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29101097 |
| http://purl.uniprot.org/citations/29101097 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29101097 |
| http://purl.uniprot.org/uniprot/#_B4DYZ9-mappedCitation-29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101097 |
| http://purl.uniprot.org/uniprot/#_C0H5Y2-mappedCitation-29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101097 |
| http://purl.uniprot.org/uniprot/#_O15164-mappedCitation-29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101097 |
| http://purl.uniprot.org/uniprot/#_B6ZGT2-mappedCitation-29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101097 |
| http://purl.uniprot.org/uniprot/#_B7Z8Q3-mappedCitation-29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101097 |
| http://purl.uniprot.org/uniprot/#_B7Z8R7-mappedCitation-29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101097 |
| http://purl.uniprot.org/uniprot/#_F1DAL4-mappedCitation-29101097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101097 |