| http://purl.uniprot.org/citations/29101316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29101316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29101316 | http://www.w3.org/2000/01/rdf-schema#comment | "Pol II transcribes diverse classes of RNAs that need to be directed into the appropriate nuclear maturation pathway. All nascent Pol II transcripts are 5'-capped and the cap is immediately sequestered by the nuclear cap-binding complex (CBC). Mutually exclusive interactions of CBC with different partner proteins have been implicated in transcript fate determination. Here, we characterise the direct interactions between CBC and NELF-E, a subunit of the negative elongation factor complex, ARS2 and PHAX. Our biochemical and crystal structure results show that the homologous C-terminal peptides of NELF-E and ARS2 bind identically to CBC and in each case the affinity is enhanced when CBC is bound to a cap analogue. Furthermore, whereas PHAX forms a complex with CBC and ARS2, NELF-E binding to CBC is incompatible with PHAX binding. We thus define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01402-w"xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01402-w"xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/author | "Cusack S."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/author | "Cusack S."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/author | "Schulze W.M."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/author | "Schulze W.M."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/pages | "1302"xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/pages | "1302"xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/title | "Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/title | "Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2."xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29101316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29101316 |
| http://purl.uniprot.org/citations/29101316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29101316 |
| http://purl.uniprot.org/citations/29101316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29101316 |
| http://purl.uniprot.org/citations/29101316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29101316 |
| http://purl.uniprot.org/uniprot/L9KL62 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/29101316 |
| http://purl.uniprot.org/uniprot/#_L9KL62-citation-29101316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29101316 |