| http://purl.uniprot.org/citations/29109831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29109831 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of the core autophagy kinase, Unc51-like kinase 1 (ULK1), is regulated transcriptionally and translationally by starvation-induced autophagy. However, how ULK1 is regulated during hypoxia is not well understood. Previously, we showed that ULK1 expression is induced by hypoxia stress. Here, we report a new ULK1-modulating microRNA, miR-93; its transcription is negatively correlated with the translation of ULK1 under hypoxic condition. miR-93 targets ULK1 and reduces its protein levels under hypoxia condition. miR-93 also inhibits hypoxia-induced autophagy by preventing LC3-I to LC3-II transition and P62 degradation; these processes are reversed by the overexpression of an endogenous miR-93 inhibitor. Re-expression of ULK1 without miR-93 response elements restores the hypoxia-induced autophagy which is inhibited by miR-93. Finally, we detected the effects of miR-93 on cell viability and apoptosis in noncancer cell lines and cancer cells. We found that miR-93 sustains the viability of MEFs (mouse embryonic fibroblasts) and inhibits its apoptosis under hypoxia. Thus, we conclude that miR-93 is involved in hypoxia-induced autophagy by regulating ULK1. Our results provide a new angle to understand the complicated regulation of the key autophagy kinase ULK1 during different stress conditions."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.org/dc/terms/identifier | "doi:10.1155/2017/2709053"xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Feng D."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "He R."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "He P."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Hou X."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/author | "Ba Z."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/name | "Oxid Med Cell Longev"xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/pages | "2709053"xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/title | "MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1."xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://purl.uniprot.org/core/volume | "2017"xsd:string |
| http://purl.uniprot.org/citations/29109831 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29109831 |
| http://purl.uniprot.org/citations/29109831 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29109831 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0B3-mappedCitation-29109831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29109831 |
| http://purl.uniprot.org/uniprot/#_Q3U0V5-mappedCitation-29109831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29109831 |