| http://purl.uniprot.org/citations/29112852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29112852 | http://www.w3.org/2000/01/rdf-schema#comment | "Great progress has been made in identifying transcriptional programs that establish stem cell identity. In contrast, we have limited insight into how these programs are down-graded in a timely manner to halt proliferation and allow for cellular differentiation. Drosophila embryonic neuroblasts undergo such a temporal progression, initially dividing to bud off daughters that divide once (type I), then switching to generating non-dividing daughters (type 0), and finally exiting the cell cycle. We identify six early transcription factors that drive neuroblast and type I daughter proliferation. Early factors are gradually replaced by three late factors, acting to trigger the type I→0 daughter proliferation switch and eventually to stop neuroblasts. Early and late factors regulate each other and four key cell-cycle genes, providing a logical genetic pathway for these transitions. The identification of this extensive driver-stopper temporal program controlling neuroblast lineage progression may have implications for studies in many other systems."xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2017.10.004"xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/author | "Thor S."xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/author | "Jonsson C."xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/author | "Ekman H."xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/author | "Gunnar E."xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/author | "Bahrampour S."xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/pages | "332-348.e4"xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/title | "Neural Lineage Progression Controlled by a Temporal Proliferation Program."xsd:string |
| http://purl.uniprot.org/citations/29112852 | http://purl.uniprot.org/core/volume | "43"xsd:string |
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| http://purl.uniprot.org/uniprot/P31368#attribution-5837A31F798E39D479F9C7F112F3814E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29112852 |
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