| http://purl.uniprot.org/citations/2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2911367 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferons (IFNs) have an important role in cell growth and differentiation. The most well-known function of IFNs is their antiviral activity; viral infections result in induction of the transcription of the IFN-alpha and IFN-beta genes. Recently we isolated the gene encoding a transcription factor, IRF-1, that may play a part in the induction of IFN genes. Interestingly, the IRF-1 gene itself is virus-inducible, suggesting the importance of de novo production of IRF-1 in IFN gene induction. Here we show that high-level expression of the cloned mouse IRF-1 gene in monkey COS cells results in the induction of endogenous IFN-alpha and IFN-beta genes without viral stimulation. Furthermore, we demonstrate the induction of these genes by an IRF-1/yeast GAL4 chimaeric transcription factor. This may be the first demonstration of the specific induction of silent chromosomal genes by transfection of a single transcription factor gene in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.org/dc/terms/identifier | "doi:10.1038/337270a0"xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/author | "Kimura Y."xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/author | "Miyamoto M."xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/author | "Barsoumian E.L."xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/pages | "270-272"xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/title | "Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1."xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://purl.uniprot.org/core/volume | "337"xsd:string |
| http://purl.uniprot.org/citations/2911367 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2911367 |
| http://purl.uniprot.org/citations/2911367 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2911367 |
| http://purl.uniprot.org/uniprot/#_P15314-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_Q0VE17-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_A8Y5B9-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_D6RH71-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_P01575-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_Q4FK18-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_Q3U5M1-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_Q5SX13-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_Q5SX14-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |
| http://purl.uniprot.org/uniprot/#_Q5SX15-mappedCitation-2911367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2911367 |