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| http://purl.uniprot.org/citations/29113699 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-4 physically interacts with caspase-1 and is believed to be a proinflammatory caspase that can induce the inflammatory form of programmed cell death (pyroptosis) and the release of mature interleukin (IL)-1β. However, the function of caspase-4 in dengue virus infection is not yet fully understood. We examined the function of caspase-4 in IL-1β production and pyroptosis during dengue virus serotype-2 (DENV-2) infection in human macrophages. In this study, DENV-2 infection increased IL-1β protein level with activated caspase-4 activity. Using primary macrophages, we observed that caspase-4 induces activation of caspase-1 and secretion of IL-1β in response to DENV-2 infection, without the need for secondary signals to stimulate the assembly of the inflammasome. These findings indicate that the regulation of caspase-1 activity by capsase-4 could represent a unique mechanism. Our data suggest that caspase-4 is upstream of caspase-1 in the pathway that regulates pyroptosis and IL-1β synthesis in macrophages during DENV-2 infection."xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imbio.2017.10.044"xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/author | "Chan K.H."xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/author | "Sze D.M."xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/author | "Leung P.H."xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/author | "Cheung K.T."xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/name | "Immunobiology"xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/pages | "356-364"xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/title | "Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection."xsd:string |
| http://purl.uniprot.org/citations/29113699 | http://purl.uniprot.org/core/volume | "223"xsd:string |
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