| http://purl.uniprot.org/citations/29113976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29113976 | http://www.w3.org/2000/01/rdf-schema#comment | "Arboviral diseases have risen significantly over the last 40 years, increasing the risk of co-infection with other endemic disease such as malaria. However, nothing is known about the impact arboviruses have on the host response toward heterologous pathogens during co-infection. Here, we investigate the effects of Chikungunya virus (CHIKV) co-infection on the susceptibility and severity of malaria infection. Using the Plasmodium berghei ANKA (PbA) experimental cerebral malaria (ECM) model, we show that concurrent co-infection induced the most prominent changes in ECM manifestation. Concurrent co-infection protected mice from ECM mortality without affecting parasite development in the blood. This protection was mediated by the alteration of parasite-specific CD8+ T-cell trafficking through an IFNγ-mediated mechanism. Co-infection with CHIKV induced higher splenic IFNγ levels that lead to high local levels of CXCL9 and CXCL10. This induced retention of CXCR3-expressing pathogenic CD8+ T cells in the spleen and prevented their migration to the brain. This then averts all downstream pathogenic events such as parasite sequestration in the brain and disruption of blood-brain barrier that prevents ECM-induced mortality in co-infected mice."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.org/dc/terms/identifier | "doi:10.15252/emmm.201707885"xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Howland S.W."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Renia L."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Lee W.W."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Ng L.F."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Claser C."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Gun S.Y."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Lum F.M."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Teo T.H."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/author | "Poh C.M."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/name | "EMBO Mol Med"xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/pages | "121-138"xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/title | "Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology."xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/29113976 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29113976 |
| http://purl.uniprot.org/citations/29113976 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29113976 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNN5-mappedCitation-29113976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29113976 |
| http://purl.uniprot.org/uniprot/#_P15702-mappedCitation-29113976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29113976 |
| http://purl.uniprot.org/uniprot/#_Q544C5-mappedCitation-29113976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29113976 |
| http://purl.uniprot.org/uniprot/P15702 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29113976 |
| http://purl.uniprot.org/uniprot/Q544C5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29113976 |
| http://purl.uniprot.org/uniprot/A0A0U1RNN5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29113976 |