| http://purl.uniprot.org/citations/29117567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29117567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29117567 | http://www.w3.org/2000/01/rdf-schema#comment | "Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication. In this study, we identified a key role for the membrane-bending host protein Reticulon 3.1 (RTN3.1A) during the replication cycle of three flaviviruses: West Nile virus (WNV), Dengue virus (DENV), and Zika virus (ZIKV). We observed that, during infection, RTN3.1A is redistributed and recruited to the viral replication complex, a recruitment facilitated via the WNV NS4A protein, however, not DENV or ZIKV NS4A. Critically, small interfering RNA (siRNA)-mediated knockdown of RTN3.1A expression attenuated WNV, DENV, and ZIKV replication and severely affected the stability and abundance of the NS4A protein, coinciding with a significant alternation and reduction of viral membrane structures in the endoplasmic reticulum. These observations identified a crucial role of RTN3.1A for the viral remodelling of host membranes during efficient flavivirus replication and the stabilization of viral proteins within the endoplasmic reticulum."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.10.055"xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.10.055"xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Simmons C.P."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Simmons C.P."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Mackenzie J.M."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Mackenzie J.M."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Aktepe T.E."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Aktepe T.E."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Liebscher S."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Liebscher S."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Prier J.E."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/author | "Prier J.E."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/pages | "1639-1654"xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/pages | "1639-1654"xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/title | "The host protein reticulon 3.1A is utilized by flaviviruses to facilitate membrane remodelling."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/title | "The host protein reticulon 3.1A is utilized by flaviviruses to facilitate membrane remodelling."xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/29117567 | http://purl.uniprot.org/core/volume | "21"xsd:string |