| http://purl.uniprot.org/citations/29120743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29120743 | http://www.w3.org/2000/01/rdf-schema#comment | "Staphylococcus aureus colonization contributes to skin inflammation in diseases such as atopic dermatitis, but the signaling pathways involved are unclear. Herein, epicutaneous S. aureus exposure to mouse skin promoted MyD88-dependent skin inflammation initiated by IL-36, but not IL-1α/β, IL-18, or IL-33. By contrast, an intradermal S. aureus challenge promoted MyD88-dependent host defense initiated by IL-1β rather than IL-36, suggesting that different IL-1 cytokines trigger MyD88 signaling depending on the anatomical depth of S. aureus cutaneous exposure. The bacterial virulence factor PSMα, but not α-toxin or δ-toxin, contributed to the skin inflammation, which was driven by IL-17-producing γδ and CD4+ T cells via direct IL-36R signaling in the T cells. Finally, adoptive transfer of IL-36R-expressing T cells to IL-36R-deficient mice was sufficient for mediating S. aureus-induced skin inflammation. Together, this study defines a previously unknown pathway by which S. aureus epicutaneous exposure promotes skin inflammation involving IL-36R/MyD88-dependent IL-17 T cell responses."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2017.10.006"xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Plaut R.D."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Lee S.K."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Stibitz S."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Zhang E."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Miller R.J."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Kao T."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Geha R.S."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Miller L.S."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Ortines R.V."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Archer N.K."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Dillen C.A."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Ashbaugh A.G."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Cai S.S."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Marchitto M.C."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/author | "Riggins D.P."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/pages | "653-666.e5"xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/title | "Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses."xsd:string |
| http://purl.uniprot.org/citations/29120743 | http://purl.uniprot.org/core/volume | "22"xsd:string |