| http://purl.uniprot.org/citations/29125121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29125121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29125121 | http://www.w3.org/2000/01/rdf-schema#comment | "Pili are critical in host recognition, colonization and biofilm formation during bacterial infection. Here, we report the crystal structures of SafD-dsc and SafD-SafA-SafA (SafDAA-dsc) in Saf pili. Cell adherence assays show that SafD and SafA are both required for host recognition, suggesting a poly-adhesive mechanism for Saf pili. Moreover, the SafDAA-dsc structure, as well as SAXS characterization, reveals an unexpected inter-molecular oligomerization, prompting the investigation of Saf-driven self-association in biofilm formation. The bead/cell aggregation and biofilm formation assays are used to demonstrate the novel function of Saf pili. Structure-based mutants targeting the inter-molecular hydrogen bonds and complementary architecture/surfaces in SafDAA-dsc dimers significantly impaired the Saf self-association activity and biofilm formation. In summary, our results identify two novel functions of Saf pili: the poly-adhesive and self-associating activities. More importantly, Saf-Saf structures and functional characterizations help to define a pili-mediated inter-cellular oligomerizaiton mechanism for bacterial aggregation, colonization and ultimate biofilm formation."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.org/dc/terms/identifier | "doi:10.7554/eLife.28619"xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.28619"xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Meng G."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Meng G."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Zeng L."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/author | "Zeng L."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/pages | "e28619"xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/title | "Structural basis of host recognition and biofilm formation by Salmonella Saf pili."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/title | "Structural basis of host recognition and biofilm formation by Salmonella Saf pili."xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/29125121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29125121 |
| http://purl.uniprot.org/citations/29125121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29125121 |
| http://purl.uniprot.org/citations/29125121 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29125121 |