| http://purl.uniprot.org/citations/29130934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29130934 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein consisting of multiple copies of ubiquitin monomers. Silencing of UBB reduces cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second polyubiquitin gene. UBB is repressed in approximately 30% of high-grade serous ovarian cancer (HGSOC) patients and is a recurrent lesion in uterine carcinosarcoma and endometrial carcinoma. We identified ovarian tumor cell lines that retain UBB in a repressed state, used these cell lines to establish orthotopic ovarian tumors, and found that inducible expression of a UBC-targeting shRNA led to tumor regression, and substantial long-term survival benefit. Thus, we describe a recurrent cancer-specific lesion at the level of ubiquitin production. Moreover, these observations reveal the prognostic value of UBB repression and establish UBC as a promising therapeutic target for ovarian cancer patients with recurrent UBB silencing."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci92914"xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Jenkins J."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Gokhale P.C."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Forrester W.C."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Sigoillot F."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "George E."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Distel R.J."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Benander C."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Goldberg M.S."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Kirschmeier P.T."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Nguyen Q.D."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Sanghavi S."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Gleim S."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Bonal D.M."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Harbinski F."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/author | "Kedves A.T."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/pages | "4554-4568"xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/title | "Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C."xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/29130934 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29130934 |