| http://purl.uniprot.org/citations/29133916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29133916 | http://www.w3.org/2000/01/rdf-schema#comment | "BRCA2-deficient cells exhibit gross genomic instability, but the underlying mechanisms are not fully understood. Here we report that inactivation of BRCA2 but not RAD51 destabilizes RPA-coated single-stranded DNA (ssDNA) structures at resected DNA double-strand breaks (DSBs) and greatly enhances the frequency of nuclear fragmentation following cell exposure to DNA damage. Importantly, these BRCA2-associated deficits are fueled by the aberrant activation of classical (c)- and alternative (alt)-nonhomologous end-joining (NHEJ), and rely on the well-defined DNA damage signaling pathway involving the pro-c-NHEJ factor 53BP1 and its downstream effector RIF1. We further show that the 53BP1-RIF1 axis promotes toxic end-joining events via the retention of Artemis at DNA damage sites. Accordingly, loss of 53BP1, RIF1, or Artemis prolongs the stability of RPA-coated DSB intermediates in BRCA2-deficient cells and restores nuclear integrity. We propose that BRCA2 antagonizes 53BP1, RIF1, and Artemis-dependent c-NHEJ and alt-NHEJ to prevent gross genomic instability in a RAD51-independent manner."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-01759-y"xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Fu C."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Xie A."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Ruan C."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/author | "Huen M.S.Y."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/pages | "1470"xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/title | "BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability."xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29133916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29133916 |
| http://purl.uniprot.org/citations/29133916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29133916 |
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| http://purl.uniprot.org/uniprot/#_A0A068BDS2-mappedCitation-29133916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29133916 |
| http://purl.uniprot.org/uniprot/#_A0A068BDS6-mappedCitation-29133916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29133916 |
| http://purl.uniprot.org/uniprot/#_A0A068BDT0-mappedCitation-29133916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29133916 |
| http://purl.uniprot.org/uniprot/#_A0A068BDU2-mappedCitation-29133916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29133916 |