| http://purl.uniprot.org/citations/29135973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29135973 | http://www.w3.org/2000/01/rdf-schema#comment | "Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Histone deacetylase 6 (HDAC6) is frequently altered in DLBCL and inhibition of HDAC6 has potent anti-tumor effects in vitro and in vivo. We profiled miRNAs that altered in the HDAC6 knockdown DLBCL cells with NanoString nCounter assay and identified microRNA-27b (miR-27b) as the most significantly increased miRNA. We validated decreased expression of miR-27b in DLBCL tissues, and we found that low expression of miR-27b was associated with poor overall survival of patients with DLBCL. In addition, forced expression of miR-27b suppressed DLBCL cell viability and proliferation in vitro, and inhibited tumor growth in vivo. Mechanistically, Rel A/p65 is found to negatively regulate miR-27b expression, and its acetylation and block of nuclear translocalization caused by HDAC6 inhibition significantly elevates miR-27b expression. Furthermore, miR-27b targets MET and thus represses the MET/PI3K/AKT pathway. These findings highlight an important role of miR-27b in the development of DLBCL and uncover a HDAC6-Rel A/p65-miR-27b-MET signaling pathway. Elevating miR-27b through HDAC6 inhibition would be a promising strategy for DLBCL treatment."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2017.299"xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Wang W.G."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Wei P."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "You M.J."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Yang Y.L."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Zhou X.Y."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Li X.Q."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Jia Y.J."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Liu Z.B."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Sun C.B."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/author | "Yu B.H."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/pages | "703-711"xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/title | "HDAC6 regulates microRNA-27b that suppresses proliferation, promotes apoptosis and target MET in diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/29135973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29135973 |
| http://purl.uniprot.org/citations/29135973 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29135973 |
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| http://purl.uniprot.org/uniprot/#_A5D6Q9-mappedCitation-29135973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29135973 |
| http://purl.uniprot.org/uniprot/#_B3KNA1-mappedCitation-29135973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29135973 |
| http://purl.uniprot.org/uniprot/#_B5A935-mappedCitation-29135973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29135973 |