| http://purl.uniprot.org/citations/29136508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29136508 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited the effect of CSF1R targeted therapy. We demonstrated that carcinoma-associated fibroblasts (CAF) are major sources of chemokines that recruit granulocytes to tumors. CSF1 produced by tumor cells caused HDAC2-mediated downregulation of granulocyte-specific chemokine expression in CAF, which limited migration of these cells to tumors. Treatment with CSF1R inhibitors disrupted this crosstalk and triggered a profound increase in granulocyte recruitment to tumors. Combining CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2017.10.005"xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Hashimoto A."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Speicher D.W."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Lo A."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Sepulveda M.A."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Ordentlich P."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Mulligan C."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Languino L.R."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Snyder L.A."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Chao T."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Weeraratna A.T."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Nam B."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Pure E."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Loboda A."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Gabrilovich D.I."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Condamine T."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Vonderheide R.H."xsd:string |
| http://purl.uniprot.org/citations/29136508 | http://purl.uniprot.org/core/author | "Donthireddy L."xsd:string |